Download Advances in Viral Genomes Research by John A. Borrelli, Ylenia D. Giannini PDF

By John A. Borrelli, Ylenia D. Giannini

ISBN-10: 1628087234

ISBN-13: 9781628087239

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Science, 2005. 308(5718): p. 83-8. , The molecular biology of memory storage: a dialogue between genes and synapses. Science, 2001. 294(5544): p. 1030-8. , Neuronal competition and selection during memory formation. Science, 2007. 316(5823): p. 457-60. , Increasing CREB in the auditory thalamus enhances memory and generalization of auditory conditioned fear. Learn Mem, 2008. 15(6): p. 443-53. , Hippocampal overexpression of mutant creb blocks long-term, but not short-term memory for a socially transmitted food preference.

In addition, the use of amplicons expressing BDNF promoted neuronal survival up to the same maximal level seen by adding exogenous BDNF, in a model of avian cochlear neuron cultures [150]. Other neurotrophins were implicated in the proper function of the auditory system. Amplicons expressing neurotrophin-3 (NT-3) were also used in murine cochlear explants model. After infection, the cochlear explants were exposed to cisplatin to induce destruction of hair cells and neurons in the auditory system.

Improved neuron survival could be attributed to the fact that the bcl-2 blocks nuclear Apoptosis-inducing factor (AIF) translocation [131]. In an experimental therapeutic approach, Lawrence and collaborators injected rats with this Bcl-2 expressing vector after ischemia induction, then leading to a reduction in neuronal loss [132]. Furthermore, they showed that there is a time window (30 minutes to 4 hours after reperfusion) where the injection was Amplicon Vectors for Gene Transfer 33 effective [132].

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