Download Advancing Prion Science: Guidance for the National Prion by Institute of Medicine, Medical Follow-Up Agency, Committee PDF

By Institute of Medicine, Medical Follow-Up Agency, Committee on Transmissible Spongiform Encephalopathies: Assessment of Relevant Science, Laura B. Sivitz, Rick Erdtmann

ISBN-10: 0309090601

ISBN-13: 9780309090605

Provides a file from the Institute of Medicine's Committee on Transmissible Spongiform Encephalopathies recommending examine to shut major gaps in current wisdom of prion ailments and methods for strengthening the U.S. study infrastructure for learning those illnesses. Softcover. DNLM: Prion ailments, prevention & control--United States.

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Extra resources for Advancing Prion Science: Guidance for the National Prion Research Program

Sample text

Third, the mechanisms of exposure to the infectious agent in nature, the routes of transmission, and the way the agent invades the host’s central nervous system must be defined. Fourth, scientists must develop surveillance systems that are sensitive enough to identify new TSEs and new TSE phenotypes. 4: Provide funds to expand research on the natural history, prevalence, distribution, exposure and transmission characteristics, host susceptibility, and host range of transmis- 17 SUMMARY sible spongiform encephalopathies, especially chronic wasting disease.

Consequently, FSIS issued a more stringent enforcement directive for the CNS tissue ban (FSIS, 2002). The most effective rapid CNS test available for beef processors cannot distinguish between CNS tissue from ruminants and that from other animals, such as pigs, which do not contract TSE (personal communication, D. Cliver, University of California, Davis, 2003). 1: Fund research to improve rapid, accurate, and affordable screening assays for central nervous system (CNS) tissue such that the assays can specifically identify CNS material from cattle in processed meat products.

This makes it difficult to attract doctoral and postdoctoral fellows, whose academic programs last for a relatively short time. 1: Provide funds to attract and train more investigators in prion disease research. In addition, for investigators conducting prion bioassay research, provide grants for 5- to 7-year periods. S. infrastructure for research on transmissible spongiform encephalopathies by expanding or upgrading existing laboratories, animal facilities, and containment laboratories (biological safety levels 2 and 3), and by building new ones.

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