By Philip S. Mellor, Matthew Baylis, Christopher Hamblin, Charles H. Calisher, Peter P.C. Mertens
African horse affliction virus is a double-stranded RNA virus which explanations a non-contagious, infectious arthropod-borne affliction of equines and infrequently canine. 9 specific, the world over known serotypes of the virus have to this point been pointed out. This e-book is predicated upon the findings of 2 programmes funded via the eu fee. it will likely be of price not just to the expert study employees but additionally to veterinary staff facing keep watch over and to legislators looking to advertise secure foreign move of equines. the themes coated contain cutting-edge discussions on diagnostics, vaccines, molecular biology, vector reports, and epidemiology.
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Extra resources for African Horse Sickness
S. , P. S. , S. D. , P. R. , and P. Wohlsein2 2 ! K. Institute of Pathology, School of Veterinary Medicine, Hannover, Germany Summary. Investigations have been carried out to elucidate the possible role of the donkey in the epidemiology of African horse sickness (AHS). These studies have shown that despite the absence of pyrexia or other observable clinical signs, donkeys become infected with virulent AHS virus serotype 4 (AHSV 4) and that they develop a viraemia which can persist for at least 12 days, albeit at a comparatively lower titre than that recorded for similarly infected ponies.
Furthermore, the currently available vaccines are developed specifically for horses and therefore may be less efficacious for donkeys, thereby leaving some animals inadequately 'protected'. 0 of infectious bluetongue virus per ml of blood would be sufficient to infect a blood feeding vector Culicoides midge. If this value is similar for AHSV then donkeys must be considered a potential source of virus for insect vectors. It has also been shown here, that the AHSV 4 recovered from an infected, but apparently healthy donkey was lethal for a pony.
Mean values recorded for the animals that responded to primary vaccination. 0-0 Antibody titres recorded for the single mule that recorded a primary type antibody response after challenge 32 H. EI Hasnaoui et al. 0 ... 0 0 10 20 30 40 50 Days 60 70 80 90 Fig. 2. The development of neutralising antibodies against AHSV 4 in sera taken from donkeys following vaccination and subsequent AHSV 4 challenge . • - . Mean value of the antibody titres recorded for the 4 donkeys positive until the day of challenge (51 dpv).