Download An Assessment of the CDC Anthrax Vaccine Safety and Efficacy by Institute of Medicine, Medical Follow-Up Agency, Committee PDF

By Institute of Medicine, Medical Follow-Up Agency, Committee to Review the CDC Anthrax Vaccine Safety and Efficacy Research Program

ISBN-10: 0309086264

ISBN-13: 9780309086264

In 1998, the dep. of safety (DoD) begun a software of crucial immunization opposed to anthrax for all army body of workers. because the software proceeded, notwithstanding, a few army team of workers and their households raised issues in regards to the safeguard and efficacy of the anthrax vaccine. Acknowledging either the necessity to defend army body of workers and the worries concerning the anthrax vaccine, congress directed the facilities for affliction keep watch over and Prevention (CDC) to hold out a examine software on its defense and efficacy. to help within the improvement of this software, CDC asked the Institute of drugs (IOM) to convene a committee to check the completeness and appropriateness of the study software. In An overview of the CDC Anthrax Vaccine protection and Efficacy learn Program, the committee makes an total review of the CDD study plan and reports the categorical experiences proposed by way of CDC within the 3 parts of efficacy, defense and acceptability. The committee additionally notes extra study wishes that turned obvious following the bioterrorist occasions of 2001 and makes options concerning the management of the study program.

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Additional info for An Assessment of the CDC Anthrax Vaccine Safety and Efficacy Research Program

Sample text

Finding: Additional studies in laboratory animals of the efficacy of AVA in combination with antibiotics following inhalational exposure to anthrax spores are needed to establish an appropriate duration for antibiotic prophylaxis after vaccine administration (see IOM, 2002). Recommendation: As part of its research plan, CDC should support studies in laboratory animals to establish an appropriate duration for antibiotic prophylaxis when administered with AVA following B. anthracis spore challenge.

Finding: Additional studies in laboratory animals of the efficacy of AVA in combination with antibiotics following inhalational exposure to anthrax spores are needed to establish an appropriate duration for antibiotic prophylaxis after vaccine administration (see IOM, 2002). Recommendation: As part of its research plan, CDC should support studies in laboratory animals to establish an appropriate duration for antibiotic prophylaxis when administered with AVA following B. anthracis spore challenge.

REFERENCES CDC (Centers for Disease Control and Prevention). 2000. S. Department of Defense, 1998–2000. MMWR (Morbidity and Mortality Weekly Report) 49(16):341–345. CDC. 2001a. Update: investigation of bioterrorism-related inhalational anthrax—Connecticut, 2001. MMWR (Morbidity and Mortality Weekly Report) 50(48):1077–1079. CDC. 2001b. Update: investigation of bioterrorism-related anthrax and adverse events from antimicrobial prophylaxis. MMWR (Morbidity and Mortality Weekly Report) 50(44):973–976.

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