By Dehmer M., et al. (eds.)
The booklet introduces to the reader a few leading edge statistical equipment which could e used for the research of genomic, proteomic and metabolomic information units. particularly within the box of structures biology, researchers try to research as many facts as attainable in a given organic method (such as a mobile or an organ). the perfect statistical review of those huge scale info is important for the proper interpretation and varied experimental ways require varied methods for the statistical research of those info. This booklet is written by way of biostatisticians and mathematicians yet aimed as a worthwhile advisor for the experimental researcher in addition computational biologists who frequently lack a suitable history in statistical research.
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Additional info for Applied Statistics for Network Biology
After all, network biology is biology and the fundamental goal is the same for network biology and molecular biology – to better understand basic biological processes and the mechanisms of human diseases. L. N. (2004) 2 3 4 5 6 7 8 9 Network biology: understanding the cells functional organization. Nat. Rev. , 5, 101–113. Bergman, A. L. (2003) Evolutionary capacitance as a general feature of complex gene networks. Nature, 424, 549–552. A. (1969) Metabolic stability and epigenesis in randomly constructed genetic nets.
The dimeric forms of repressor and cro bind to these binding sites to regulate the transcription of genes cI and cro [78, 79, 83]. Biochemical reactions in this system are classiﬁed into fast reactions and slow reactions. Fast reactions include two monomer–dimer reactions and binding reactions of ligands to the promoter sites, and they are assumed to be in an equilibrium state. Slow reactions represent transcription and degradation. A complete list of the possible binding conﬁgurations and the corresponding free energy of these conﬁgurations can be found in [85, 88].
Brieﬂy, Response Net is a ﬂow optimization algorithm that redeﬁnes a crucial subnetwork that connects genetic hits (source) and differentially expressed genes (target) from a whole weight network, where each node or edge has been assigned a weight according to their biological importance or conﬁdence. The cost of an edge is deﬁned by the Àlog value of its weight. Thus, the goal of Response Net can be achieved by solving a linear programming optimization problem that minimizes the overall cost of the network when distributing the maximal ﬂow from source to target.